Normal Distribution
nothing is called 95% until it has been counted
Concept

Normal approximation — where it appears

Replacing a statistic's exact distribution by a normal one of the same mean and variance. How good it is depends on the tails of what is being summed rather than on how many terms there are, which is why a sum over a handful of rare events is not normal at any sample size.

Named by 8 essays across 6 fields — each of them below, with the objects they name alongside it.

The normal approximation's error on a sum of 100 exponential draws, under its Berry–Esseen bound. The distance between the exact distribution function and the normal one peaks at 0.0133, at z = -0.01. The Berry–Esseen bound is 0.1146, 8.62 times the real worst error, and larger than the whole 2.5% tail a two-sided test reads.

A bound written for a coin

The Berry–Esseen theorem guarantees how far a standardised sum can be from the normal, and the guarantee is true. On an exponential source it is 8.62 times the real worst error at every sample size, the worst error sits at the centre rather than in a tail, and at a hundred draws the bound is larger than the 2.5% tail it would be asked to vouch for.

expansion · Rate A model of the active set, and the active set. Each of the 14 units of one design, at the share of its exchanges the tolerance box blocks — computed from the design's columns and the tolerance under a uniform position in the box, against counted over all 116 admissible assignments. The diagonal is where the two would agree. Over 192 designs they agree about the ordering of the units at a correlation of 0.8141 ± 0.0112, negative on 0.5% of them, and disagree about the level: 0.8442 counted against 0.8170 modelled, a gap of 0.0272 ± 0.0051. An admissible assignment does not sit uniformly in its box, and this is the size of that.

A model and a count

The share of a unit's exchanges a tolerance box refuses can be modelled from the design or counted over the admissible set. They order the units the same way at a correlation of 0.81 and disagree about the level by 0.027.

blocked · Randomisation Ten groups of 10, pooled on the log-odds scale. Each row is a group. The hollow circle is its own proportion, the filled one is the estimate after pooling, and the vertical rule is the pooled population proportion of 31.3%. One group saw no events at all, and its raw proportion of zero becomes 21.2% — an estimate the group's own data cannot produce and the population's can. The arrows are not the same length, and none of the groups differs in size.

Pooling a proportion

A proportion cannot be shrunk on its own scale — an estimate would leave the interval, and how much information a count carries depends on where it sits. Move to log-odds and the approximation works, at the price of a group that saw nothing having no estimate at all until the correction supplies one.

multilevel · Levels Where the normal approximation converges, and where it does not. Relative error against the exact binomial. At n = 1280 the error at the median is 0.96% and three sigma out it is 25.7% — a factor of 27. The tail is where the approximation is used.

The tail converges last

The central limit theorem is usually shown as a shape arriving. What the demonstration leaves out is the rate — and the rate is wildly different in the middle and in the tail, which is where every approximation in the subject is actually read.

normal · Rate The upper tail of 10 exponential draws: normal, one Edgeworth term, two Edgeworth terms, each against the exact tail. Each curve is an approximation divided by the exact gamma tail, so 1 is exact. Six standard deviations out at n = 10: the normal gives ×0.0000670, one Edgeworth term ×0.00159, two ×0.0167 and the saddlepoint ×1.0007.

A correction that goes below zero

One Edgeworth term takes the normal approximation's error at two standard deviations from 38% to 8% on ten exponential draws, and stretches the range within 10% of the truth from 1.66 to 3.09 standard deviations at a hundred. It also turns negative in the short tail at every sample size — past 3.13 standard deviations at a hundred draws and 9.83 at a hundred thousand — because the region recedes only as the sixth root of n.

expansion · Rate The chance a trial succeeds against its size, when the expected effect of 0.5 is uncertain by four amounts. With the effect known, 80% is reached at 63 per arm. With the effect uncertain by 0.25 standard deviations it takes 113; by 0.5, 1268; by 0.75, no sample size at all, because the chance can never exceed the 74.8% prior probability that the effect is positive.

The chance a trial succeeds

A trial of sixty-four per arm has 80% power at an effect of half a standard deviation. If the effect is only believed to be about half a standard deviation, give or take a quarter, the chance the trial reaches significance is 69.2%; give or take a half, 61.4%. Reaching 80% then takes 113 per arm, or 1,268 — and when the belief is uncertain by three quarters of a standard deviation no number of patients reaches 80%, because the chance can never exceed the 74.8% probability that the effect is positive at all.

planned · Power The upper tail of 10 exponential draws: normal, two Edgeworth terms, saddlepoint, each against the exact tail. Each curve is an approximation divided by the exact gamma tail, so 1 is exact. Six standard deviations out at n = 10: the normal gives ×0.0000670, one Edgeworth term ×0.00159, two ×0.0167 and the saddlepoint ×1.0007.

An approximation built at the threshold

The saddlepoint approximation reads the tail of a sum of five exponential draws to within 0.19% six standard deviations out, where the normal is short by a factor of more than sixty thousand. It is within 2.2% out to ten standard deviations on a single draw, where there is nothing to average, and within 1.1% on a binomial whose expected count is one. It works because it is built where the tail is read rather than at the mean.

expansion · Rate Power at an effect of 0.5 standard deviations. The curve is the non-central t on 2n − 2 degrees of freedom with δ = d√(n/2); the dots are 4,000 experiments run at each size. Reaching 80% power needs 64 per arm.

How many subjects

Sixty-four per arm for 80% power at half a standard deviation — a power figure that could only be simulated, with nothing to disagree with, until the non-central t was written. Two routes now, agreeing to within the simulation's own error.

design · Power

Named alongside it

The objects these essays reach for when they reach for this one.

Tail probabilityApproximation errorCentral limit theoremConvergence rateDiscretenessSample sizeSkewnessBerry–EsseenEdgeworth expansionEffect sizep-valuePrior

All concepts