Normal Distribution
nothing is called 95% until it has been counted
Concept

Effect size — where it appears

How large the difference being looked for is, stated in units of the noise it has to be seen against. Power, sample size and the value of an experiment are all functions of it, and none of them is defined without one.

Named by 12 essays across 6 fields — each of them below, with the objects they name alongside it.

The eighth was not a constant. The probability that a per-candidate tuning list changes which candidate the table selects, at each of 5 separations between the candidates, over 800 draws apiece. The earlier field reports this flat at about an eighth across list length, on a table and a world it never varies. Vary how much the omitted coefficients are worth — one multiplier, with the table, the list, the law and the sample size all held — and it runs from 17.6% to 1.5%, a factor of 11.75. The world in which every candidate is true is the world in which the tuning list decides most; the world in which one candidate dominates is the world in which it decides nothing.

The eighth that was not a constant

How often a per-candidate tuning list changes which candidate wins is reported flat at about an eighth across list length. Vary how far apart the candidates are instead and it runs from 17.6% to 1.5%.

turnover · Order-selection Two factors, opposite directions. The two factors the cost of a per-candidate tuning parameter is a product of, as the candidates are pulled apart, over 800 draws at each of 5 separations. How often the candidates disagree about the tuning parameter rises from 31.8% to 88.8%; the share of those disagreements that change which candidate the table selects falls from 51.6% to 1.7%. So the setting where the candidates quarrel most about the tuning parameter is the setting where the quarrel matters least, and a sweep that reads the rate and stops has read the factor pointing the wrong way.

Two factors pointing opposite ways

As the candidates on a table are pulled apart, they quarrel about the tuning parameter three times as often and the quarrel decides the winner thirty times less often. A sweep that reads the first factor has read the one pointing the wrong way.

turnover · Order-selection Power at an effect of 0.5 standard deviations. The curve is the non-central t on 2n − 2 degrees of freedom with δ = d√(n/2); the dots are 4,000 experiments run at each size. Reaching 80% power needs 64 per arm.

What a p-value does not say

The same p of 0.04 corresponds to a large effect in ten observations and a negligible one in two thousand. A p-value alone cannot be interpreted, and the number that makes it interpretable is almost never printed beside it.

testing · Power Naming the analysis in advance, against correcting for all 20 of them. The prespecified analysis detects an effect that is in it 52% of the time at two standard errors and an effect elsewhere 5% of the time. The corrected slate detects it 23% of the time wherever it is. The two are worth the same when the chance of having named the right analysis is 38% — and that figure rises to 91% at four standard errors.

What naming it in advance costs

Preregistration is argued for as free. Against an effect of two standard errors hiding in one of twenty analyses, naming the right one detects it 51.5% of the time and naming the wrong one detects it 4.7% of the time; correcting all twenty detects it 22.5% wherever it is. The two are worth the same when the chance of having named correctly is 38%.

paths · Forking The chance a trial succeeds against its size, when the expected effect of 0.5 is uncertain by four amounts. With the effect known, 80% is reached at 63 per arm. With the effect uncertain by 0.25 standard deviations it takes 113; by 0.5, 1268; by 0.75, no sample size at all, because the chance can never exceed the 74.8% prior probability that the effect is positive.

The chance a trial succeeds

A trial of sixty-four per arm has 80% power at an effect of half a standard deviation. If the effect is only believed to be about half a standard deviation, give or take a quarter, the chance the trial reaches significance is 69.2%; give or take a half, 61.4%. Reaching 80% then takes 113 per arm, or 1,268 — and when the belief is uncertain by three quarters of a standard deviation no number of patients reaches 80%, because the chance can never exceed the 74.8% probability that the effect is positive at all.

planned · Power Power to find a real effect of 3 standard errors, 10 of 20 real. no correction finds 85.1%, Bonferroni finds 49.1%, Holm finds 52.5%, Benjamini–Hochberg finds 74.9%. The uncorrected procedure finds the most and controls nothing.

The price of control

Every correction is paid for in power, and the exchange rate can be measured. Holm buys familywise control for 33 percentage points of power; Benjamini–Hochberg buys a weaker guarantee for 10. Neither is free and neither is a matter of taste.

multiplicity · Multiplicity What the family-wise correction does to the effect it lets through. At two standard errors the estimate that clears an uncorrected 5% threshold averages 1.35 times the truth, and the one that clears the family-wise threshold averages 1.69 times it. The correction fixes the error rate by demanding a larger estimate, and a larger estimate is a more selected one.

The correction that makes the estimate worse

Correcting for twenty analyses repairs the p-value by demanding a larger statistic, and a larger statistic is a more selected one. At two standard errors the surviving estimate averages 1.35 times the truth before the correction and 1.69 times it after — so the honest error rate is bought with a more inflated effect.

paths · Forking How much of a normal outcome's information survives cutting it into two, by where the cut is. For a small shift, a cut at the mean keeps 63.7% of the information, so the trial needs 1.57 times the sample. A cut at the top tenth keeps 34.2% and needs 2.92 times; a cut two standard deviations out keeps 13.1%.

An outcome cut in two

Replacing a measured outcome with whether it crossed a threshold keeps 63.7% of the information when the cut is at the mean, 34.2% at the top tenth and 13.1% two standard deviations out. A trial that needs 63 patients per arm on the measured outcome needs 102 cut at the mean and 185 cut at one and a half standard deviations. The responder rates that result read as a share of patients who respond — 50.0% against 69.1% — when every patient moved by the same amount; and a cut chosen after looking turns a 5% test into a 17.7% one.

planned · Power Power at an effect of 0.5 standard deviations. The curve is the non-central t on 2n − 2 degrees of freedom with δ = d√(n/2); the dots are 4,000 experiments run at each size. Reaching 80% power needs 64 per arm.

How many subjects

Sixty-four per arm for 80% power at half a standard deviation — a power figure that could only be simulated, with nothing to disagree with, until the non-central t was written. Two routes now, agreeing to within the simulation's own error.

design · Power The same dial, on a list that steps by one. The probability that a per-candidate tuning list changes which candidate the table selects, at each of 5 separations, for both tuning parameters at a matched list length of 8. The sieve order runs from 13.1% to 2.6%, a factor of 5.00; the whitening window, from 16.4% to 1.5%, a factor of 11.75. What is held is the number of options, the table, the law, the sample size and the seeds; what cannot be held is the size of a step, since an integer step and a geometric step are different amounts of change. The dial moves both, and it moves them by 2.35 times as much on one as on the other.

A step that is not a ratio

Run the separation sweep on a tuning list of integers rather than a geometric ladder and the two factors still point opposite ways. The invariant does not survive: along a row of integers the probability moves by 2.163 where along the geometric ladder it moves by 1.208.

turnover · Order-selection The p-value of a study with 80% power, twenty thousand times. Twenty thousand two-sided z-tests, each on 25 observations whose true mean is 0.5603 standard deviations from the null, a noncentrality of 2.802. The bars are the counted share of p-values in bins a quarter of a power of ten wide, with the leftmost bin holding everything smaller; the line is the closed form. The middle eighty per cent of the p-values runs from 4.4×10⁻⁵ to 0.13, 3.46 orders of magnitude, the median is 0.0051, and 80.0% fall below 0.05, which is what the power means.

The p-value a replication gets

Under a true null a p-value is flat. Under a real effect its distribution is closed form and wide — a study with 80% power returns anything from 4.4×10⁻⁵ to 0.13 in eight runs of ten — and the chance that an exact replication of a p = 0.05 result is significant again is exactly one half, under both of the models people use without naming them.

testing · Uniformity Every finding Benjamini–Hochberg made in thirty families, with its interval, at real effects of 2. 85 findings, sorted by their estimate. 12 of their ordinary 95% intervals miss the true effect, every one of them on the far side; 6 of the wider false-coverage-rate intervals miss.

Intervals for the findings

Benjamini–Hochberg's findings usually go out each with its ordinary 95% interval. With ten real effects of two standard errors among twenty tests, 11.59% of those intervals miss their effect, every miss on the far side, and the interval around the most prominent finding covers 72.36% of the time — 2.38% when the effects are one standard error. Intervals widened for the number of findings hold the share that miss under 5%.

multiplicity · Multiplicity

Named alongside it

The objects these essays reach for when they reach for this one.

Statistical powerMonte CarloSample sizeMultiple comparisonsSelection effectBandwidth selectionConditional distributionDependenceFalse positiveInformation criterionModel selectionNested models

All concepts