Field

Reversals that are not errors

Simpson's reversal, the base rate, regression to the mean. Each is normally taught with one famous table. A table is a point; these are swept, so how much of the space behaves that way and how large it can get both have answers — including why two correct analyses of one baseline disagree, how far a group enrolled on a noisy reading falls with nothing done to it, and why the correlation predicts the regression of the extremes only when the population is normal.
Which allocations reverse the overall comparison. The per-group success rates are held fixed; only the split of each group between treatment and control changes. 32% of the allocations reverse, and the worst reverses by 13.1 percentage points.

Simpson's reversal is a region, not a table

The treatment wins in both groups and loses overall. That is normally shown with one famous table, which cannot answer the two questions a reader has — how often, and how large. Swept, it turns out to occupy 31% of the allocation space.

What a positive test means, sensitivity 90%, specificity 95%. At a prevalence of one in a thousand, 98 of every hundred positives are false. At one in 10, 33 are. The test has not changed.

What a positive test is worth

A test that is 90% sensitive and 95% specific sounds accurate. For a condition affecting one person in a thousand, 98% of its positive results are wrong, and a worse test on a commoner condition beats a better test on a rare one.

Two measurements of the same thing, correlated 0.60. Pick the worst 15% on the first measurement and their average rises by 0.78 on the second. Pick the best and theirs falls by 0.48. No treatment was given to anybody.

Regression to the mean

Select the worst performers, measure them again, and they improve. Select the best and they decline. No intervention is required for either, the size of the apparent effect is predictable from the correlation alone, and it is the reason so many things appear to work.

Two groups, a baseline and a follow-up, and nothing happening in between — baseline reliability 0.6. 600 units in two pre-existing groups whose true means are 1.00 apart, read once at baseline and once at follow-up, with no change for anybody. The two groups' mean changes are −0.075 and −0.032, so the change-score analysis reports a group difference of 0.043. The regression of follow-up on baseline and group reports 0.409, against a closed form of (1 − λ) × 1.00 = 0.400: at any one baseline reading the two groups' lines sit that far apart, because each group's units regress towards their own group's mean. The pooled slope in this sample is 0.614, the baseline's reliability.

Two analyses of one baseline

Two groups read at baseline and again at follow-up, with no change for anybody. Subtracting the baseline reports a group difference of −0.0014 and adjusting for it reports 0.4008 — and each analysis is exactly right about one reason the groups started apart and wrong by 0.40 about the other.

A cohort screened once, the top tenth enrolled, and followed up with nothing given — correlation 0.6. 2000 people read once at screening and once at follow-up, with a test–retest correlation of 0.6 and no treatment. The 215 above a cut at the top ten per cent of one reading (1.282 standard deviations) are enrolled. Their mean screening reading is 1.744 and their mean follow-up reading 0.982, a fall of 0.762 ± 0.055 with nothing done to anyone. The closed form for the fall is (1 − ρ) times the truncated-normal mean, (1 − 0.6) × 1.755 = 0.702.

The measurement that got them enrolled

Enrol the top tenth of one screening reading and give them nothing, and they fall by 0.702 standard deviations at follow-up. Measured from a fresh reading taken after enrolment they fall by nothing. Averaging ten screening readings still leaves 0.101, and it takes twenty-one to get under 0.05.

The top of a heavy-tailed population keeps its lead; the top of a light-tailed one gives it back. Select the top share on the first reading and read the group again: the share of its mean lead the second reading keeps, by integration over the true score (lines) and counted on 400,000 draws a parent in 20 batches (points, with two standard errors). The normal keeps exactly 0.6 at every selection. At the top half the Laplace keeps 0.541, the t 0.535 and the uniform 0.648 — the heavy tails keep LESS than the correlation. By the top one per cent the order has reversed: 0.761, 0.784 and 0.443. At one in ten thousand the t keeps 0.977 and the uniform 0.346.

A lead that a heavy tail keeps

Four populations whose readings all correlate at exactly 0.6, and whose least-squares slopes all read 0.6. Select the top one per cent on one reading and measure them again: they keep 60% of their lead if the true scores are normal, 76.1% if they are Laplace, 78.4% if they are a t on four degrees of freedom — and 44.3% if they are uniform. The correlation predicts the regression of the extremes for one shape of population only.

Twenty studies of a thousand readings estimate the regression of the extremes: the t, four degrees parent. Each thin line is one study of 1000 readings from the t, four degrees parent: Tweedie's formula with the log-density's slope estimated by a degree-5 log-spline, drawn up to that study's largest reading. The thick line is the share kept by integration over the true score, and the dashed line the correlation, 0.6. The top ten readings of the median study begin at 2.45. Over 400 studies the corrected share kept by the top one per cent averages 0.8190, with a spread of 0.0806, against 0.7842 by integration; a Gaussian kernel averages 0.7914 with a spread of 0.0853.

The slope of a density nobody can see

Tweedie's formula corrects a reading by the slope of the readings' own log-density, and a study has its readings. Estimated from a thousand of them, the correction for the top one per cent beats the correlation's linear rule on 84.0% to 98.0% of studies from heavy-tailed populations and on 75.0% to 81.5% from a bounded one — and costs an error of 0.09 to 0.12 where the population is normal and the rule was already exact. At 250 readings the log-spline loses to the rule it replaces, and at 16,000 the same log-spline gets worse on a power tail.

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