Sequential design — where it appears
Named by 10 essays across 4 fields — each of them below, with the objects they name alongside it.
A block size that changes
The blinded rule's exactness never needed the blocks to be the same size. Letting the size be chosen from the contrasts as the run goes on leaves the coverage exactly where it was — and runs straight into an identity that says what a schedule can and cannot buy.
Two degrees of freedom, one total
The block size is a dial, and the two things a fixed-width procedure claims move in opposite directions along it. Divide the width by the square root of the sample size and one of them turns out to depend on the number of blocks and on nothing else.
Stopping when it is precise enough
An experiment that runs until its estimate is precise enough is the natural design and the one with a theorem against it. Its two-stage cousin keeps its promise exactly, for every unknown spread, and pays twice the observations for it.
What a schedule actually buys
Big blocks early and small blocks late is the right instinct and it does not take both ends of the trade, because there are not two ends to take. What it does take is the overshoot — about four per cent of the observations — and a steadier stopping point.
A schedule that reads the mean
The block sizes may be anything at all provided they are functions of the contrasts. Two natural schedules break that, in opposite directions — and the most natural mistake of the three is not a schedule at all but a stopping rule, at 86.87% coverage and fewer observations.
The interval after a stop it chose
A rule that stops when the estimated precision is good enough stops on the samples whose estimate was small. Its interval covers 90% and claims 95%, and a fresh sample of the same random size covers 95.4%.
How much of the forbidden spread a rule may read
A stopping rule that reads the spread its interval will report breaks the interval. Blend that spread into what the rule reads, a share at a time, and the cost is not proportional to the share — at a tight requirement a rule can read four fifths of it before anything is lost, and the last fifth costs nearly four points.
The fifth a third stage never reaches
A three-stage stopping rule keeps the two-stage rule's independence and the sequential rule's budget. With a first stage of five it covers 88.4% — worse than the rule it was meant to repair — because in a fifth of experiments the second stage buys nothing.
A bootstrap that repeats the design
After a design that chose its settings from the data, a parametric bootstrap can keep the settings the experiment ran or repeat the whole procedure from the start. On twelve runs repeating it changes coverage by a point at most, because the adaptivity was nearly free. What matters is the interval's shape: the percentile bootstrap covers 90.6%, no better than the Wald interval's 91.3%; the studentised one 93.0%; the profile interval 94.9%. And after a design stuck at a twelvefold wrong guess, the studentised bootstrap — the textbook repair — covers 77.8%, with intervals averaging 54.5 wide for a parameter of 3.
Augmenting a design that has already run
The equivalence theorem still certifies when some runs are already spent, and one number in it changes: the bound is no longer p but (p − λ·tr(M⁻¹M_fixed))/(1 − λ). It equals p again exactly when the runs already made can still be absorbed into the design that would have been chosen — so the certificate says whether the experiment is still recoverable.
Named alongside it
The objects these essays reach for when they reach for this one.
CoverageFixed-width intervalMonte CarloStopping ruleConfidence intervalBlockingDegrees of freedomSample sizeBlindingNuisance parameterExperimental designIndependence