Main effect — where it appears
Named by 2 essays across one field — each of them below, with the objects they name alongside it.
One factor at a time
Changing one thing per experiment estimates each effect from two conditions; changing everything at once estimates each from every run. The ratio is (k+1)/2 and it is exact — and when two factors interact, the one-at-a-time design recommends a setting it never tried.
The word a fraction costs
A half fraction estimates each main effect as an exact sum of that effect and everything it is confounded with — no error term, no sample-size argument. With every interaction at 0.8 the design reports a true effect of −1 as −0.20, and the design cannot test the assumption that makes the number mean anything.
Named alongside it
The objects these essays reach for when they reach for this one.
Factorial designInteractionAlias structureConfoundingDesign resolutionExperimental designFractional factorialHidden replicationLeast squaresReplicationStudy design