Normal Distribution
nothing is called 95% until it has been counted
Concept

Greenwood's formula — where it appears

The standard error of a Kaplan–Meier estimate: the estimate times the square root of a running sum of d/(n(n − d)) over the event times so far. With nobody censored it is exactly the binomial standard error, and an interval built symmetrically from it stops covering near the end of the curve.

Named by 2 essays across one field — each of them below, with the objects they name alongside it.

Kaplan–Meier from 120 subjects, 59 of them censored. The step curve is the estimate, the smooth curve is the truth it is trying to recover. 59 of 120 subjects were still event-free when observation stopped; they are not dropped, and they are not counted as events — they leave the risk set at the time they were last seen.

The curve that survives censoring

Kaplan–Meier recovers the true survival curve to within a fraction of a point at every censoring level from 37% to 71%, where dropping the censored subjects is off by 28 and then by 43. The estimator is a running product and the reason it works is in its denominator.

survival · Censoring One cohort of 40, and two intervals around the end of its curve. A single simulated study of 40 subjects with exponential survival at rate 0.35, dropout at rate 0.15 and follow-up to 6 — the first seed from 8811 upward whose plain band reaches below −0.05, chosen to show the failure rather than its frequency. The step curve is Kaplan–Meier and the smooth curve the truth. The plain band, the estimate plus and minus 1.96 Greenwood standard errors, first dips below zero at t = 3.78 and reaches −0.052; early on it also rises to 1.023, above one. At t = 5 the estimate is 0.069 with 1 subject still under observation, the plain interval runs from −0.052 to 0.191 and the log-log interval from 0.006 to 0.251, against a truth of 0.174. The log-log band is built on a scale that cannot leave [0, 1], and it bends away from the edge rather than through it.

The interval at the end of the curve

The interval most software prints around a survival curve covers 89.7% at five years, where 3.3 of forty subjects are still being watched and where the curve is actually read. The same variance carried on a log–log scale covers 94.8% there — and the failure was never the width.

survival · Censoring

Named alongside it

The objects these essays reach for when they reach for this one.

CensoringKaplan–MeierRisk setSurvival curveBinomial proportionConditional coverageConfidence intervalCoverageMonotone transformationMonte CarloMultiple comparisonsWald interval

All concepts