Covariate balance — where it appears
Named by 88 essays across 21 fields — each of them below, with the objects they name alongside it.
A basis is a subspace
A balancing rule cannot tell one basis from another with the same span, so choosing what to hand it is choosing a subspace — and then what it removes of any outcome shape is a projection, computable exactly, with no trial anywhere in it.
A cut is not a polynomial, and it does not have to be
A threshold's expansion never terminates, which is why a balancing dictionary's geometry was closed for powers and taken to draws for cut points. Conditioning on the second variable closes it for both.
A dictionary that is a product
Two covariates make what a balancing rule may read an outer product — eight main effects and sixteen interactions — and every inner product in it is still closed form. What a rule holding all eight main effects removes of a pure interaction is not small. It is zero.
A dictionary that is neither
A rule handed two median splits removes none of their interaction; a rule handed two covariates removes none of their product. Those were two results with two explanations, and they are one result with one — and finding it corrected the number underneath both.
A margin that turns over
A skewed covariate's leak grows without limit as the dependence strengthens. A copula's own leak does not — it peaks at a rank correlation of 0.6 and falls. The margin of the table turns over before any cell in it does.
A proposal that moves more than two units
The walk's autocorrelation is a fact about its step size and not about its acceptance rate. Exchanging three units from each arm mixes nearly twice as fast as exchanging one, and is refused a third more often.
A test rather than a survey
A thin admissible set falls into an arrangement and its mirror image, and the walk that samples it is uniform on half the reference distribution for ever. That was found by enumerating fourteen units, and enumeration stops at twenty-four.
A zero that is arithmetic
A median split's exact zero was explained by a symmetry of the latent normal. It holds under a Clayton copula, which has no such symmetry, because a centred median split squares to a quarter identically.
A zero that rests on a symmetry
A balancing rule removes exactly none of an interaction between two odd functions, at every correlation. The argument needs the joint sign flip to preserve the law, and no real covariate is symmetric about anything.
Balanced on the wrong function
A rule that reads a covariate's numbers halves the variance of the treatment estimate, if the covariate enters the outcome as a straight line. If it enters as a threshold the rule is worth a fifth of that, and if it enters as a curve every rule here is worse than a coin.
Balancing what is known in advance
Four allocation rules, three definitions of balance, and no rule that holds more than one of them. Minimisation keeps the worst factor margin near three patients whether the trial has forty or six hundred and forty — and lets the imbalance in the cross-classified cells climb to 86% of a coin's, because the cells are not what it is watching.
The fourth moment that was missing
Mehler's formula makes the main effects exact at any correlation and stops there, because the interactions need an expectation of four Hermite functions rather than two. A linearisation turns the four into two, and the whole geometry becomes closed again.
The part the rule already took
A diagnostic that reports on what a balancing rule was not handed is run through a column that is 92% inside the span the rule balanced — because orthogonality in the population is not orthogonality on fourteen units.
The statistic the p-value is about
The test for whether a balanced-assignment walk reaches its whole set is run on a covariate function chosen before the trial. Run on the difference in arm means it is the same test, and it is about the number the trial publishes.
Three arms and three scores
Minimisation balances a trial by keeping the arms' counts even inside every prognostic factor. With two arms there is one way to measure how uneven two counts are. With three there are several, they are all called minimisation, and they send different patients to different arms.
Two failures that cancel
A mildly skewed covariate under a lower-tail copula leaks 0.002% of an interaction where each failure alone leaks eight and seven per cent. Turn the copula over and the same pair compounds.
What the rule blocks
A balancing rule breaks the admissible set into pieces by refusing exchanges. Which exchanges it refuses is computable from the design and the tolerance alone, before any assignment exists — and it makes a probe.
A score that balances
Weighting each unit by one over its own assignment probability drives the standardised difference between the arms from 0.8310 to 2.8×10⁻¹⁷ — exactly, not nearly. A score fitted without the second covariate leaves that covariate at 0.7057, further apart than doing nothing at all.
The reversal a coin cannot prevent
Randomisation removes Simpson's reversal in expectation, which is not the same as removing it. A correctly randomised trial of eighty units, on a population where the treatment helps in both groups, reports it losing overall on 3.40% of trials — and stratifying the randomisation takes that to zero at every size.
A model and a count
The share of a unit's exchanges a tolerance box refuses can be modelled from the design or counted over the admissible set. They order the units the same way at a correlation of 0.81 and disagree about the level by 0.027.
A probe chosen from the design
The design's own leverage aligns with the separating direction four times better than a random direction in the same subspace. The concentrated direction the argument invites is worse than random.
A probe nobody chose
On a set that is definitively in two pieces, seven of twenty-four outcomes report nothing at all. Every covariate probe reports it. What separates them is not accuracy — it is that one of them can be chosen and the other is what happened.
A split survives what a mean does not
The two things every trial balances come apart on a skewed covariate. A median split is a function of the sign of the latent normal whatever the marginal is; a mean is not, and its exact zero is gone at a skewness of one.
A symmetry that was not enough
A heavy-tailed symmetric covariate has a skewness of zero and leaks exactly nothing under three copulas. Under the two asymmetric ones it doubles the leak, from 7.707% to 14.229%.
A threshold in the tail
How much of a threshold's imbalance a balanced covariate removes is a correlation, and the correlation is a closed form. At the median it is exactly 2/π — the same 2/π a median split throws away — and two standard deviations out it is an eighth.
A zero that was an assumption
A rule handed every main effect of both covariates removes exactly none of a pure interaction. That is true at machine precision, it is a fact about independence, and it dies as the square of the correlation.
Balancing towards unequal targets
A three-arm trial allocating two to one to one is the ordinary case, and a balancing rule built from raw counts does not know it. It balances the arms towards equality inside every factor level, delivers a third to each arm, and reports that it minimised imbalance.
Randomisation is not balance
A third of all ways to split sixteen units leave the two halves more than half a standard deviation apart on a covariate. What randomisation delivers is not balance but a known reference distribution — and it makes a test exact with no assumption about the data's shape at all.
Stationary is not convergent
A walk that exchanges every unit in each arm preserves the uniform distribution exactly and never gets near it. Every doubly stochastic matrix has the same stationary distribution; only some of them have a limit.
The arcsine that closes it, and the error that was overstated
Two median splits of a correlated pair agree with probability ½ + arcsin(ρ)/π, exactly. And the truncation the field was avoiding falls geometrically in the correlation, not algebraically in the order.
The rule that can be guessed
A balancing rule improves as it becomes more deterministic, and a deterministic rule can be worked out in advance from information the person enrolling the patient already has. At full determinism 87.6% of assignments are guessable, and an investigator who acts on the guess produces a treatment effect of three quarters of a standard deviation where the truth is zero.
The statistic that changes sign
A test for an unreachable half needs a quantity that tells one half from the other. Every symmetric reading of a mirror pair is identical, and a magnitude is the natural thing to reach for.
The symmetry the marginals could not show
A mean's interaction zero needs the covariate to be symmetric and the copula to be symmetric under reflection. Six marginals could only ever test one of those, and the other is broken by the commonest kind of dependence there is.
What the extra function buys
A rule balancing the mean of each covariate has a worst case of exactly zero. Adding the median split — the other thing every trial balances — leaves it at exactly zero, and one square moves it.
Where the enumeration stops
A maximin over an eight-function dictionary is a walk over seventy subsets. Over twenty-four it is 735,471 at eight functions, and the exchange algorithm that replaces the walk scores 421. What licenses the second curve is four sizes where both exist and agree, which is a weaker warrant than it looks.
Which shapes are worth protecting
Choosing a basis by its worst case is a finite problem with an exact answer. The answer has no tie in it, which a maximin optimum is supposed to have — and the tie comes back, along with twice the guarantee, when the basis is drawn rather than chosen.
The zero that was a crossing
A cell that leaks 0.002% where adding its two halves gives 16.6% is a field's headline. On a finer grid it passes through zero at a rank correlation of 0.38 — two hundredths from where it was measured.
A copula that halves a marginal
Three copulas break nothing on their own and put a factor of two between the same skewed covariate's leaks — 12.118% under a Frank against 23.640% under a t, at the same rank correlation.
A count that has to be estimated
At sixteen units the admissible assignments can be counted by walking all 12,870 of them. At four hundred there are about 2^393.70, and the share admitted is 0.31885 against a closed form of 0.31818 that has no trial size in it at all. The exhaustion a small trial runs into is a fact about small trials.
A defect that is about size
The admitted share of a rerandomisation barely moves with the number of units. The number of admissible neighbours grows like the square of it, and that is what decides whether the walk can go everywhere.
A quantity that loses to a heuristic
Leverage is a heuristic about which units a balancing rule has most to say about. The constraint's active set is the thing the rule actually does. As a probe, the heuristic wins by 4.4 paired standard errors.
An answer that changes
Eleven of twenty cells cancel and nine compound, at one rank correlation. Sweep the correlation and four of the twenty change sides — all four from compounding to cancelling, all four at the most skewed covariates.
Half a reference distribution
A walk that reaches half its admissible set reports the two-sided p-value exactly right, to the last digit, for ever. A one-sided one it puts on the wrong side of five per cent about once in thirty.
The cut that is not a quantile
A protocol that says split the covariate at a threshold and one that says split it at the median read the same and are different rules. One has an exact guarantee under every marginal and the other has none under any.
The set a dictionary leaves
A rule constrained on six functions at a loose tolerance leaves a set as thin as one constrained on three at a tight one. Both sampling methods cross over at the same thinness, and the tolerance where that happens moves by a factor of three.
The zero that survives a cut
A rule holding both main effects removes half of a pure interaction between correlated powers and exactly none between correlated median splits. The guarantee that a correlation destroyed was never about interactions.
Three functions of one number
A rule that balances the covariate is exposed to every shape the outcome might have. A rule that balances three functions of it costs two points of variance against the shape the first was built for and takes the worst case from a coin's to about half of it.
Walking the admissible set
A rerandomisation test hunts for admissible assignments and throws away the rest. A walk visits them instead — and it is exactly uniform only because it stands still when a proposal fails, which is the step that looks like waste.
What a chosen probe finds
On a chain of eight hundred draws the probe the earlier fields use misses 44% of the sets that are split. Its own residual off the rule's span misses 12%, for one least-squares fit.
Where the gain is, and where the decision is
A bigger proposal is worth a factor of six at a loose tolerance and nothing at a tight one. The tolerances where it helps are the ones where a hunt costs two evaluations a draw, and the crossing barely moves.
Where the guarantee is exactly zero
An experimenter who declines to name the shapes, and asks instead to be protected against anything in a class, is asking for a number that is not small but zero. Bounding the class is unavoidable, and the two ways of doing it choose different bases.
Which tail the cut sits in
The same copula and its reflection have the same rank correlation, the same Kendall tau and the same marginals. A balancing rule holding a threshold at a dose leaves 5.33% under one and 33.36% under the other.
Balancing a skewed covariate
The worst case of the rule every trial runs goes from exactly zero to somewhere between a quarter of a per cent and two and a half. Which is small, and is a number that cannot be stated without the covariate's distribution in it.
Before the trial and after
The same diagnostic run at two moments answers two different questions. Before, a positive verdict changes the design. After, it changes which number gets reported — and only for the numbers the defect can reach.
Counting it exactly does not help
If a modelled active set lost because the model was crude, the exact one would win. It is computed at a cost no trial can pay, and it is worse — so the approximation was never what was costing the probe.
The analysis and the shape
An unadjusted analysis after a rule that read the covariate is too cautious — by a third against a linear outcome, by nothing at all against a quadratic. And an adjustment for the wrong function recovers almost none of the precision the right one would.
The diagnostic at two hundred
Pointed at a trial size no enumeration reaches, the test gives three answers rather than one — and past a certain thinness it stops agreeing with itself, which is the honest reading and the one nothing could give before.
The walk that cannot cross
A thin enough admissible set is not one set. It splits into an assignment and its mirror image, no sequence of admissible single swaps joins them, and the walk that samples it is uniform on half the reference distribution for ever.
The zero that survives both
A median split's interaction leak is under 10⁻¹⁶ at all thirty combinations of copula and marginal. It is the only guarantee in the collection that neither half of the dependence can touch.
What a reference distribution costs to sample
A randomisation test on a trial too large to enumerate has to sample its reference distribution, at 1/p attempts per draw and a p-value resolved to 1/(B + 1). Six constraints cost 9,878 attempts per thousand draws, and a thousand draws resolve p to 9.99·10⁻⁴ and not one digit finer.
When the constraints run out
Every function added to a basis is a constraint the assignment has to satisfy with the same units. At sixteen units and a stated tolerance the admissible assignments run 3,874, then 1,006, then 314, then none — and the count is exact, because the assignment space is finite.
A cut walked into the tail
Move a balancing rule's threshold off the median and the interaction it leaks rises from exactly zero — and then either turns back to nothing or climbs to a ceiling, depending on one property of the dependence. With both covariates cut, the whole regression collapses to two probabilities, and far out it settles on 2λ/(1 + λ) of the tail-dependence coefficient: 57.25% under a Clayton, 35.57% under a t, and zero under a Gaussian or a Frank however strongly the covariates are related.
How far to project
The field's repair for a probe is to project it off the span the balancing rule already pinned. Treated as a dial rather than a switch, that repair is right all the way for the fourth power — its separation rises from 1.543 unprojected to 5.080 fully projected — and wrong for the design's own leverage, which carries 4.537 unprojected, 4.924 at four tenths of the way and only 3.836 projected fully. The leverage probe the field recommended was a third of the way past its best. Even the separating direction itself gains a little from a partial projection and loses a little from a full one.
The other dial
The table is swept along the strength of the dependence and never along the shape of the covariate. Swept along the shape at a fixed correlation, the same two copulas cross, the same way — and the near-zero cell turns out to be a minimum in both directions at once.
A set of pairs, not a vector
The active set is a graph on the units, and every probe built from it so far has been its degree. Read as a graph it recovers 0.1326 of the alignment the summary lost — and draws level with leverage rather than passing it.
A median with ties
The median split's interaction zero survives every marginal and every copula, because a split that is on for exactly half the units squares to a constant. A covariate measured on a few levels cannot be split exactly in half: on a five-point scale three in eight units sit on the median, and a rule balancing 'above the median' removes 6.39% of the interaction under a Gaussian copula and 10.06% under one of the two Claytons. The size is set by the share of units on the median, which is the formula's own factor. And a fair coin for the tied units restores the zero exactly, on every copula.
Where the skew puts a threshold
The field read the mean-balancing rule along a sequence of skewness and left the threshold rule — a cut at a fixed value on the covariate's own scale — unread. Read, it turns out to be no new curve. Skewing the scale moves the value 1 from the 84th percentile of the latent covariate to the 74th, and the rule's leak is the copula field's cut sweep read at that quantile: it falls on every copula, from 16.41% to 10.07% under a Gaussian. Whether skew and dependence compound or cancel is then a fact about the slope of each copula's curve, and unlike the mean rule's, no cell changes its answer along the sequence.
What the ellipse spends its assignments on
Rerandomising on Mahalanobis distance never runs out of assignments, where a box of per-function tolerances does at four functions. But at the same number of admissible assignments it holds the worst named function half as tightly, because it spends its constraint on a combination of the basis nobody named.
A basis drawn rather than chosen
On two covariates no fixed basis of one or two functions protects every shape an outcome might have — its worst case is exactly zero. Draw the basis at random from the right mixture and the guarantee is a fifth of a shape for every function. The price is per trial — at three functions, two draws in five leave one shape wholly unprotected.
Two functions a covariate
Every constraint costs admissible assignments at the same rate, so the decision a trial faces is a budget: which two functions of each covariate. Over twenty-eight pairs the worst case never picks the mean. At a correlation of a half it picks the square with a cut at one, beating the mean and the square by sixteen hundredths of a point on a floor held by a shape no pair removes a tenth of — and giving up 41% of a linear outcome to do it. Over the 127 lists of shapes a designer could write, twenty-three different pairs are best somewhere.
How many functions a trial can hold
A rule that reads more functions of one covariate protects more shapes, and every function it reads costs the shapes it already held: the imbalance it leaves in a linear outcome falls like one over the trial size, with a constant that runs from about 3 for one function to about 16 for six. At fifty units that cost eats the protection, and the worst case over four shapes sits between 37% and 42% of a coin's from two functions to six. At four hundred it falls from 42% to 6%. By six functions the worst shape, at every size, is one the rule is reading.
The share a sample removes
A rule balancing eight main effects of two independent covariates removes exactly none of their interaction — in the population. A trial is a sample, and in a sample of a hundred units exact balance on the same eight functions removes 24% of the interaction's variance on average, between 10% and 42% from one trial to the next. At twenty-five units it removes 62%. The zero is the centre of nothing: it is the limit the in-sample share falls towards, by about two fifths with every doubling of the trial, carried there by an interaction whose spread grows with the very functions it is regressed on. At a correlation of a half the closed form says 64%; a trial of a hundred gets 69% on average and anything from 53% to 83%.
A share at a hundred units
On a skewed covariate the closed form credits a rule that balances the means with removing 26% of the covariates' product and 52% of a square, shares that rest on symmetry having failed. A trial does not collect them. At a hundred units the rule removes 12% of the product and 37% of the square on the clearly skewed covariate, and at four hundred units barely more, because the shares live in the long tail and the tail is a handful of units. On the most skewed covariate the rule removes a fifth of the median split at a hundred units and nothing of it at four hundred: balancing the mean of such a covariate is balancing its largest few values.
A ceiling that is one unit
The benchmark every probe of a split admissible set was measured against maximised the wrong thing, so the obvious next step was the direction that maximises the separation itself. On 88 of 100 split designs that direction has no finite value: some combination of units reads the same on every assignment of a component. On 83 of them it is a single unit, sitting in one arm across one component and the other arm across the other — and a chain can see a unit that never moves without enumerating anything.
A leak read off a two-by-two table
The share of an interaction a threshold-balancing rule leaves alone needs one number from the data: how often a unit past the cut on one covariate is past it on the other. A cohort of a thousand estimates it to within a dozen points at the 90th percentile. At the 99th most cohorts have an empty cell in their table, and every one of those reads a leak of exactly one hundred per cent — a reading the bootstrap then confirms with an interval of zero width.
A unit that has not moved
At two hundred units the two-chain diagnostic could not settle its own verdict, because its standard error needed a relaxation time the run was too short to estimate. Reading which units moved needs no standard error. Run for 1.6 million steps on five designs, it finds a unit in place in both chains on three designs at the tightest tolerance and one at the next — and every one of them is a unit no swap can move from any admissible assignment, by arithmetic. The admissible set does split at two hundred units, and the split is one extreme unit.
After the mirror is gone
The two-chain diagnostic starts its second chain at the complement of the first's start, which exists only when the arms are equal. At five treated against ten, enumerated on two hundred designs, a split admissible set is one big piece and some crumbs — the median puts 97.3% of its assignments in one component — so two random starts see the split on 12% of split designs and 95% needs a median of 109 starts. Worse, the rule fixes units in a connected set all the time, so a unit that never moves stops being evidence. A hunt that forces such a unit into the other arm finds 41 of 70 splits; 29 carry no unit that marks them.
A weight fitted to balance
Weights fitted so that each arm's weighted covariate means equal the sample's leave a difference of 1.4×10⁻¹⁴ between the arms and give the estimate a third of the variance of weights fitted by likelihood — 0.011883, within a relative 5.8% of the bound no estimator can beat. In the world where the assignment carries a square nobody named, the same exact balance leaves the square further apart than no weighting at all, and where the outcome carries it too the estimate is wrong by 0.6973 with an interval that covers 1.5%.
How far, not whether
The blocking matrix records whether a tolerance box refuses an exchange. Dropping the pairs it refuses for certain changes nothing. Recording instead how far each exchange moves the balance vector turns the pairing into its degree plus a part that lies inside the rule's own span — and the degree is the design's leverage, exactly. The heuristic that beat every reading of what the rule blocks was the unclamped pairing's degree all along.
The zero that needed two
A rule balancing two median splits removes nothing of their interaction, on every copula, because a centred split squares to a constant. Add a third covariate and the same arithmetic stops protecting the thing it looked as if it protected. The product of three splits is not orthogonal to the mains: at a rank correlation of 0.4 a rule on the mains removes 14.47% of it under a Gaussian copula. And the symmetry that decides the rest belongs to the triple rather than the pair, so Frank's copula, whose pairs are radially symmetric, leaks where Clayton's, whose pairs are not, barely does.
A cut on each side
Every table of the threshold's leak put one quantile on both covariates, which is the diagonal of a surface nobody had drawn. Off the diagonal the copulas swap places: a cut at the 5th percentile on one covariate and the 95th on the other removes 54.8% of the interaction under a Gaussian copula and 1.1% under a t copula, the reverse of their order at the near corner. Walked further out, the far corner has two opposite limits, and which one a Gaussian reaches is decided by whether its correlation is above or below exactly one third.
The list it was chosen on
Six functions of one covariate looked like 720 designs, one per order of addition. The rule reads a span and not a sequence, so they are 63, and at a hundred units the best four leave 12.1% of a coin's imbalance against the designer's first four at 31.5%. Those best four contain no cube and are, function for function, the four shapes the worst case was scored on. Read on six shapes it was not told about, the same design leaves the cube 77.0% of a coin's imbalance, and the designer's four, which lost by a factor of two and a half, leave it 28.1%.
A second reading or a second covariate
A rule that balances a recording balances the truth only as far as the recording reaches, and a second reading of the covariate raises that reach. So does a first reading of something else. At a reliability of 0.8 the first reading of a second covariate does more once that covariate matters a third as much as the first, and the threshold is exact: the square root of (1 − λ)/(1 + λ), with no trial size in it. A protocol's list of measurements turns out to be a small knapsack, and it is rarely filled by reading anything twice.
A floor for the draw
A basis drawn at random guarantees more on average than any fixed one, at the price of leaving some shape wholly untouched in a large share of trials. Requiring every basis in the draw to keep a floor looks like a smooth trade between the two. It is a staircase, and the first step does nearly all the work. No basis has a floor between zero and 31.83%, so there is nothing to give up until a floor of that size is asked for. And at four functions, seven bases tie at the fixed basis's own 63.66%: a mixture of them keeps that floor exactly and adds thirteen points to the guarantee.
A box with a count
The ellipse never runs out of assignments and holds the named functions loosely; the box holds them tightly and can come up empty. Dropping the ellipse's thin directions was meant to give both, and it does not: no cutoff comes within a third of the box. But the box's emptiness was never a property of the box. It belongs to a tolerance fixed in advance. Set the tolerance by a count instead, and at that count the region is the box, on every set of units, with nothing left to run out.
The covariate on its ranks
A skewed covariate spoils every parity argument a balancing rule relies on, and a rule that balances ranks instead of values looks like the way out, since a rank has the same uniform law on any marginal. The measurement says the skew really does belong to the scale for one kind of shape: a rank holds a median split at exactly a quarter of a coin's imbalance whatever the covariate. But it pays with a cap on any shape linear in the value, at nearly half a coin's imbalance on the strongest skew. And a rule holding values and median splits together holds both, beating the rank on the shape a rank gives up and matching it on the one it gains.
The moments a balance is told
Weights fitted to balance the covariates' means were wrong by 0.6973 in the world where both the assignment and the outcome carry a square. Told the squares and the product as well, the same construction is off by −0.0045 there and its interval covers 91.0%. The failure moves up a moment rather than away: with a cube in both, the second-moment balance is off by 0.3099 and leaves the cube twice as far apart as no weighting. And where overlap is thin, 37.0% of samples have no such weights at all.
A balance allowed a tolerance
Weights that balance the means exactly and the second moments only to within a tenth of a standard deviation were supposed to keep the second-moment repair and recover the samples exact balance loses. Where a square drives both the assignment and the outcome they keep neither half of the repair: the bias is 0.2782 against −0.0074 with exact balance, and the interval covers 26.5%, because the weights spend the whole tolerance — every second-moment gap sits at the edge of its band — and the outcome converts a gap of a tenth into bias at its own slope, 2·δ·√2 = 0.283. At thin overlap the same tolerance does recover samples: 89.0% have weights at all, against 62.0% with exact balance.
Named alongside it
The objects these essays reach for when they reach for this one.
Closed formInteractionBasis functionsImbalanceRandomisation testRerandomisationExperimental designProjectionOrthogonalityReference distributionAssignment mechanismExact enumeration